Sunan ciniki | UniAPI-PBS |
CAS | 1405-20-5 |
Sunan samfur | Polymyxin B sulfate |
Bayyanar | Fari ko kusan fari foda |
Solubility | Ruwa mai narkewa |
Aikace-aikace | Magani |
Assay | Jimlar polymyxin B1, B2, B3 da B1-I: 80.0% minPolymyxin B3: 6.0% maxPolymyxin B1-I: 15.0% max |
Kunshin | 1kg net da aluminum iya |
Rayuwar rayuwa | shekaru 2 |
Adanawa | Ajiye a wuri mai sanyi da bushewa, nesa da haske. 2 ~ 8 ℃ don ajiya. |
Tsarin Sinadarai |
Aikace-aikace
Polyxin B sulfate shine maganin rigakafi na cationic surfactant, cakuda polyxin B1 da B2, wanda zai iya inganta haɓakar ƙwayar sel. Kusan mara wari. Mai hankali ga haske. Hygroscopic. Mai narkewa a cikin ruwa, dan kadan mai narkewa a cikin ethanol.
Tasirin asibiti
Bakan sa na ƙwayoyin cuta da aikace-aikacen asibiti suna kama da polymyxin e. yana da tasirin hanawa ko ƙwayoyin cuta akan ƙwayoyin cuta na Gram, irin su Escherichia coli, Pseudomonas aeruginosa, paraescherichia coli, Klebsiella pneumoniae, acidophilus, pertussis da dysentery. A asibiti, ana amfani da shi musamman don kamuwa da cututtukan da ke haifar da ƙwayoyin cuta masu mahimmanci, kamuwa da tsarin urinary wanda Pseudomonas aeruginosa ke haifarwa, ido, trachea, meningitis, sepsis, ƙonewa, kamuwa da fata da mucosa, da dai sauransu.
pharmacological mataki
Yana da tasirin antibacterial akan Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Haemophilus, enterobacter, Salmonella, Shigella, pertussis, pasteurella da Vibrio. Proteus, Neisseria, Serratia, pruvidens, Gram-positive kwayoyin cuta da kuma wajibi anaerobes ba su kula da wadannan kwayoyi. Akwai juriya tsakanin wannan magani da polymyxin E, amma babu juriya tsakanin wannan magani da sauran maganin rigakafi.
Ana amfani da shi musamman don rauni, urinary tract, ido, kunne, kamuwa da cutar trachea wanda Pseudomonas aeruginosa ke haifar da shi da sauran Pseudomonas. Hakanan za'a iya amfani dashi don sepsis da peritonitis.