Ƙirƙirar ƙirar ɗanyen abu

Kwayoyin halittar kai taro

--a iyakacin kore chemistry ba tare da watsewar bond da sake haɗawa

Babban ka'ida na haɗin kai na kwayoyin halitta:

1. Kamar jan hankali kamar - tuƙi irin waɗannan abubuwa don tarawa da tsara juna, da abubuwan da ke da alaƙa don jawo hankalin juna.

2. Mafi ƙanƙanta makamashi- motsi al'amura da halayen kwayoyin halitta zasu kasance da kwanciyar hankali. Hanya ce don tsara ƙungiyoyin ƙwayoyin cuta zuwa sifofi na ci gaba.

Ƙaddamarwar tsarin haɗin kai na kwayoyin halitta, tsarin CP tsakanin kwayoyin halitta na iya inganta aikin ilimin halitta:

1. Kowane kwayar halitta yana da tsarinsa na musamman da kaddarorin aiki, kuma yana da wuya a cimma daidaituwa da daidaitaccen jiyya bisa ga hadawa kyauta a matakin ƙira.

2. Har yanzu akwai ƙwayoyin ƙwayoyin cuta da yawa waɗanda ke da kyakkyawan aikin ilimin halitta waɗanda suka iyakance sha da aikace-aikacen su sosai saboda munanan halayensu.

3. Abubuwan da ake amfani da su na magungunan gargajiya na kasar Sin sun kasance musamman game da "sarki, ministoci da mataimaka", maimakon hodgepodge na mafi kyau.

Tsarin tsarin supramolecular gyare-gyare da ƙirar tsarin bincike ingantawa:

1. Ƙwaƙwalwar ƙwaƙƙwalwar ƙwaƙƙwalwar ƙididdiga don nunawa da sauri na abubuwan da suka dace daga Cibiyar Bayanai ta Cambridge Crystal.

2. Yi amfani da ka'idar aiki mai yawa don nazarin tsarin supramolecular da kaddarorin taro da aka ƙaddara ta hanyar ƙungiyoyin ƙwayoyin cuta, da kuma tantance wane nau'in supramolecular shine yanayin samuwar.

3. Ta hanyar nazarin yanayin amsawa da wahala, an inganta tsarin supramolecular.

4. Lissafi na daban-daban kaddarorin na supramolecules, ciki har da lantarki, na gani da kuma thermodynamic Properties.

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6.Ta hanyar fasahar docking na kwayoyin, wuraren hulɗar tsakanin kayan albarkatun supramolecular da sunadaran sunadaran suna annabta, kuma an kwatanta tsarin hulɗar tsakanin kwayoyin halitta a cikin zurfi.

Fasahar gishiri na Supramolecular eutectic/Ionic

Fasalolin fasaha: farkon masana'antar, nuna mafi kyawun abubuwan CP na abubuwan da ke aiki don ƙarfafa eutectic

Abũbuwan amfãni: rage hangula, inganta solubility, inganta ayyuka, inganta permeability, inganta kwanciyar hankali

Misalan sinadaran: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

Abubuwan da ke aiki na halitta waɗanda aka ɗauka daga kasida na albarkatun kayan kwalliya, bayan gwaje-gwaje na tabbatarwa kamar kwaikwaiyon sinadarai, babban aikin nunawa, ingantawar Gaussian, KingDraw, MestReNova, FTIR, da NMR, samfuran da aka samu suna da kyakkyawan tsarin kristal mai girma uku, kwanciyar hankali mai kyau, Tsafta mai ƙarfi, ƙarancin ƙazanta. Yana iya magance abubuwan zafi na aikace-aikacen yadda yakamata na kayan aikin abinci, magani da kayan kwalliya, da haɓaka haɓakar halittu da amincin kayan aikin.

Fasahar cire ayyukan supramolecular

Fasalolin fasaha: Na farko masana'antar, haɗin fasahar ƙwaƙƙwaran ƙwayoyin ƙwayoyin cuta da abubuwan kaushi na supramolecular na halitta, ingantaccen haɓakar kayan aikin shuka.

Abũbuwan amfãni: Ƙirar da aka yi niyya, haɓakar haɓakar haɓakawa yana ƙaruwa da sau 5 idan aka kwatanta da hakar barasa, kuma an ƙara haɓakar ruwa sau 20; babu rabuwa, rage farashin, Sinadaran haɓaka shigar azzakari cikin farji Misalai: zaitun (oleuropein, hydroxytyrosol), rhodiola, phyloporus na magani, farin ruwa Lily, micrococcus

Halin zurfin eutectic ƙarfi (NaDES): Masana kimiyya sun fara gano shi a cikin nazarin metabolomics shuka. A lokacin wasu matakai na ci gaba na tsire-tsire (germination, cryopreservation), sel za su samar da wani ruwa mai ɗanɗano ba tare da izini ba daga ruwa da lipids, kama da cakuda eutectics.

Dangane da zamani kore rabuwa fasaha, hadedde membrane fasahar, complemented ta ultrasonic / obin na lantarki kayan haɓɓaka aiki fasaha don cimma low zazzabi, niyya, high ciency, high quality da kuma kore hakar na aiki components.Through da na halitta supramolecular sauran ƙarfi kamar yadda inganci hakar sauran ƙarfi, shi solves da yawa matsaloli kamar low yadda ya dace, high kudin da wahala a sharar gida ruwa dawo da na gargajiya phyto da aka zaba tsantsa. Zaɓaɓɓen kaushi na supramolecular yana da ingantaccen aiki da ingantaccen narkewar abubuwan da ke aiki, haka nan ana iya haɓaka haɓakar haɓakar ta sau 20.

Fasahar shigar da supramolecular synergistic

Fasalolin fasaha: Na farko masana'antar, ta hanyar daɗaɗɗen supramolecular synergistically inganta shigar azzakari cikin farji na macromolecules/ruwa-soluble/masu wahala ga sha sinadaran

Fasaha abũbuwan amfãni: ingantattun kwanciyar hankali, rashin lalacewa da ingantaccen shigar da haɓakawa, tasirin haɗin gwiwa, haɓakar jagora a cikin dermis, da haɓakar bioavailability ya karu da sau 5-7 Misalai: collagen, Bosein, peptide jan ƙarfe blue, hexapeptide, fili peptide, β-glucan.

Tun da nauyin kwayoyin peptide har yanzu yana da girma idan aka kwatanta da sauran kayan aiki masu aiki, shigar da fata yana da ƙananan ƙananan. Ana buƙatar wasu hanyoyin haɓaka shigar ciki don haɓaka tasirin ƙarar shigar ciki na peptide, ta yadda za a sami ƙarancin maida hankali da inganci mai girma, da samun ingantaccen ingantaccen rigakafin tsufa.

A mayar da martani ga masana'antu ciwon batu na matalauta shigar azzakari cikin farji, high hydrophilicity da low bioavailability na gargajiya macromolecules, da JUNAS Time barbashi kayayyakin kira via jimla sunadarai taimaka, iya kai tsaye isa epidermis da dermis na fata ta hanyar trans-cellular, intercellular da follicular gumi ductchannels. Ba tare da lalata tsarin fata ba.Biyanen samfurin yana ƙaruwa da sau 5, gami da fiye da 45% a cikin dermis, ba tare da lalata tsarin fata ba. An sami nasarar haɓaka tasirin shiga da lokacin zama.Wannan shine farkon irinsa a cikin masana'antar.

Fasahar biocatalysis na Supramolecular

Bioenzyme-directed catalysis: Ana amfani da kaushi na supramolecular azaman abubuwan haɓaka aikin enzyme, haɓaka zaɓin chiral, da cimma babban tsarki.

Injiniya Fennel kore fermentation: zaɓi halaye shuke-shuke, inganta abun ciki na aiki sinadaran, anhydrous dabara, inganta overall inganci

Reverse micellar fermentation fasahar: nunin halayen halayen, fermenting man kayan lambu, ƙarin tasiri, inganta jin daɗin fata da haɓaka sha.

Dangane da fasahar recombinant gene, fasahar cloning mataki daya da fasaha mai girma bioenzyme catalytic, ana amfani da kwayoyin da aka yi amfani da su azaman dillalai don gane yawan samar da abubuwa masu aiki:

A karkashin tsarin narkewar supramolecular, enzyme yana nuna babban aiki, zaɓi da kwanciyar hankali, babban amfani da albarkatun ƙasa, ƙarancin gurɓataccen gurɓataccen tsari a cikin tsarin samarwa, yanayi mai sauƙi, babban aikin aminci da aikin samarwa.

Mai da fasahar fermentation micelle:

Zaɓaɓɓen mai na halitta tare da halayen Sinanci lP an tsara su ba tare da bata lokaci ba don samar da surfactants a ƙarƙashin aikin ƙwayoyin cuta na ƙwayoyin cuta.lt an haɗa shi azaman mai ɗaukar nauyin anti-micellar don gane dam ɗin anti-micellar dam na kayan aiki mai narkewa na ruwa don cimma yanayin yanayin aikace-aikacen, ƙwarewar fata ta ƙarshe, da ƙwarewa, ƙwarewa, ƙwarewa, ƙwarewa, inganci.

Fasahar microencapsulation na supramolecular

Fasalolin fasaha: liposome encapsulation, sakin da aka yi niyya na sel dermal, sakin da aka yi niyya na follicles gashi, da kuma sakin abubuwan masu kumburi.

Abũbuwan amfãni: Nanoization, daidaitaccen bayarwa, ɗorewa mai ɗorewa, rage fushi, inganta kwanciyar hankali, da haɓaka haɓakawa.

Misalan sinadarai: astaxanthin, glabridin, bitamin A, peptide jan ƙarfe blue, biotin, ceramide, mai mahimmancin shuka.

Supramolecular microencapsulation fasahar dogara ne a kan liposome, mai emulsion, ionic ruwa stabilization fasahar, dermal cell niyya fasahar saki, gashin follicle niyya saki fasahar, da kumburi factor amsa fasahar.Ta hanyar samar da wucin gadi sufuri tashoshi, samfurin zai iya sadar da aiki sinadaran daidai. lt yana da kyakkyawan ƙimar ɗaukar transdermal, tsawon lokacin zama da kyakkyawan kwanciyar hankali a wurin da fata ke fata. Hakanan yana da ƙarancin farashi da aikace-aikace masu inganci a fagen kayan kwalliya, abinci mai aiki da magunguna.

Fasahar haɗin kai mai matsayi na Peptide

Fasalolin fasaha: tsarin masana'antu na farko, ƙa'idar da aka yi niyya na tsarin sarƙoƙin amino acid da polypeptides, gajerun peptides masu haɗa kansu, polypeptides supramolecular

Hanyar fasaha: Inganta amphiphilicity, haɓaka kwanciyar hankali da juriya na zafi, rage yawan guba da damuwa na rigakafi, haɓaka sha, da daidaitawa.

Misalai na sinadaran: supramolecular carnosine, peptide protein yisti

Haɗin kai na sunadaran da peptides ba kawai a ko'ina ba ne a cikin tsarin rayuwa, amma har ma yana da kyau kwarai da gaske ga jikin ɗan adam, kuma ɗayan ingantattun hanyoyin haɗa kayan nano-halitta. Tsarin haɗin kai na peptide tsari ne na taro na matsayi, kuma "tsarin amino acid na polar" wani sabon nau'i ne na babban tsarin sakandare, wanda zai dace da taron manyan peptides don samar da tarawar da aka ba da umarni.

Ƙa'idar jagora na girman gajerun peptides za a iya cimma ta hanyar canza hydrophobicity da sassan sassan sassan sassan hydrophobic.

Dangane da tushen Shinehigh Innovation na musamman na ProteinDataBank (PDB), haɗa tare da duban gwaji na yau da kullun, haɓakar kwayoyin halitta da ƙididdige ƙididdigar sunadarai don nazarin tsarin ƙwayoyin peptide, sa'an nan kuma daidaita su tare da manyan ƙwayoyin haɗin kai.Modulation na nau'in, adadin da ƙayyadaddun tsarin amino acid ɗin su don canza matsayinsu na peptide. ta haka inganta ikon kwayoyin halitta don hada kai. Gane tsarin da aka yi niyya na peptides. peptide mai haɗin kai yana da kyakkyawar amphiphilicity da kuma daidaitawa, wanda ke inganta ingantaccen kwanciyar hankali na peptide, ikon transdermal da bioavailability.