Ƙirƙirar kayan aiki masu ƙirƙira

Haɗa kai na kwayoyin halitta

--wani sinadari mai launin kore na gaba ba tare da karya haɗin gwiwa da sake haɗawa ba

Babban ƙa'idar haɗa kai ta kwayoyin halitta:

1. Kamar yana jan hankali kamar - yana tuƙa abubuwa iri ɗaya don tattarawa da shirya juna, da kuma abubuwa masu halaye masu dacewa don jawo hankalin juna.

2. Mafi ƙarancin kuzari—motsi na abu da ɗabi'ar ƙwayoyin halitta za su fi zama mafi kwanciyar hankali. Hanya ce da za a tsara ƙungiyoyin ƙwayoyin halitta zuwa cikin ci gaba mai ɗorewa.

Tsarin CP tsakanin kwayoyin halitta na iya inganta ayyukan halittu sosai:

1. Kowace kwayar halitta tana da tsari na musamman da halayen aiki, kuma yana da wuya a cimma haɗin kai da kuma magani daidai bisa ga haɗakarwa kyauta a matakin hadawa.

2. Har yanzu akwai ƙwayoyin halitta da yawa waɗanda ke da kyakkyawan aikin halittu waɗanda suka takaita sha da amfani da su sosai saboda mummunan halayensu.

3. Sinadaran da ke aiki a maganin gargajiya na kasar Sin suna da matuƙar muhimmanci ga "sarki, ministoci da mataimaka", maimakon hodgepodge na mafi kyau.

Tsarin gyaran tsarin sama da ƙasa da kuma ingantawa:

1. Ana amfani da na'urar tantancewa mai ƙarfi ta hanyar kwamfuta don tantancewa cikin sauri na abubuwan da suka dace daga Cibiyar Bayanai ta Cambridge Crystal.

2. Yi amfani da ka'idar aiki mai yawa don nazarin tsarin supramolecular da halayen haɗuwa da aka ƙayyade ta hanyar ƙarfin intermolecular, da kuma tantance wane nau'in supramolecular ne yanayin samuwar.

3. Ta hanyar nazarin yanayin amsawar da wahalar da aka sha, an inganta tsarin supramolecular.

4. Lissafi na halaye daban-daban na supramolecules, gami da halayen lantarki, na gani da na thermodynamic.

5. Lissafi na halayen spectral kamar molecular spectrum da makamashi spectrum.

6. Ta hanyar fasahar docking na kwayoyin halitta, ana hasashen wuraren hulɗa tsakanin kayan albarkatun ƙasa na supramolecular da sunadarai masu manufa, kuma an bayyana tsarin hulɗa tsakanin kwayoyin halitta da zurfi.

Fasahar gishirin ionic/supramolecular eutectic

Siffofin Fasaha: na farko a masana'antar, tantance mafi kyawun abubuwan CP na abubuwan aiki don ƙarfafa eutectic

Fa'idodi: rage ƙaiƙayi, haɓaka narkewar ruwa, inganta aiki, haɓaka iskar oxygen, inganta kwanciyar hankali

Misalan sinadaran: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

Sinadaran da ke aiki a zahiri an samo su ne daga kundin kayan kwalliya, bayan gwaje-gwajen tabbatarwa kamar kwaikwayon sinadarai na quantum, tantancewa mai yawa, ingantawa gaussian, KingDraw, MestReNova, FTIR, da NMR, samfuran da aka samu suna da kyakkyawan tsarin lu'ulu'u mai girma uku, kyakkyawan kwanciyar hankali, Tsabta mai yawa, ƙarancin ƙazanta. Yana iya magance matsalolin amfani da sinadarai masu aiki a cikin abinci, magani da kayan kwalliya yadda ya kamata, da kuma inganta samuwar sinadarai da amincin sinadaran aiki.

Fasahar fitar da ayyukan sama-sama

Siffofi na fasaha: Na farko a masana'antar, haɗin fasahar buga kwayoyin halitta da kuma sinadaran da ke cikin ƙasa mai ƙarfi, ingantaccen cire sinadaran da ke aiki a cikin shuka

Fa'idodi: Cirewar da aka yi niyya, ingancin cirewar yana ƙaruwa da sau 5 idan aka kwatanta da cirewar barasa, kuma cirewar ruwa yana ƙaruwa da sau 20; babu rabuwa, rage farashi, Sinadaran da ke haɓaka shigar ciki Misalan: zaitun (oleuropein, hydroxytyrosol), rhodiola, Phyloporus na magani, farin ruwa lily, micrococcus

Natural depth eutectic solution (NaDES): Masana kimiyya ne suka fara gano shi a cikin nazarin metabolism na tsire-tsire. A lokacin wasu matakan ci gaban tsirrai (ƙwai, cryopreservation), ƙwayoyin halitta za su samar da ruwa mai kauri ba tare da ruwa da lipids ba, kamar cakuda eutectics.

Dangane da fasahar rabuwar kore ta zamani, fasahar membrane mai hadewa, wacce aka karawa ta hanyar fasahar haɓaka ultrasonic / microwave don cimma ƙarancin zafin jiki, niyya, babban inganci, inganci mai kyau da kuma cirewar kore na abubuwan aiki. Ta hanyar sinadarin supramolecular na halitta azaman sinadarin cirewa mai inganci, yana magance matsaloli da yawa kamar ƙarancin inganci, tsada mai yawa da wahala a cikin dawo da ruwan sharar gida na cirewar phytochemical na gargajiya. An zaɓi sinadaran supramolecular da aka cire don aikinsu. Maganin supramolecular da aka zaɓa yana da aiki mai ƙarfi da haɓaka narkewar sinadaran aiki, haka nan ana iya ƙara ingancin cirewa da sau 20.

Fasahar shigar da sinadarai masu haɗaka ta sama (Supramolecular synergistic)

Siffofin Fasaha: Na farko a masana'antar, ta hanyar sinadarin da ke cikin supramolecular, yana haɓaka shigar ƙwayoyin macromolecules/wanda ke narkewa cikin ruwa/wanda ke da wahalar sha sinadaran.

Fa'idodin fasaha: ingantaccen kwanciyar hankali, ingantaccen haɓaka shigarwar ciki mara lalata da inganci, tasirin haɗin gwiwa, wadatar da kai a cikin fata, da kuma wadatar bioavailability ya ƙaru da sau 5-7 Misalan sinadaran: collagen, Bosein, peptide na jan ƙarfe shuɗi, hexapeptide, peptide mai haɗawa, β-glucan.

Tunda nauyin kwayoyin halitta na peptide har yanzu yana da girma idan aka kwatanta da sauran sinadarai masu aiki, shigar fata ba ta da yawa. Ana buƙatar wasu hanyoyin inganta shigar peptide don inganta tasirin shigar peptide, don cimma ƙarancin yawan aiki da inganci mai yawa, da kuma cimma ingantaccen tasirin hana tsufa.

Saboda matsalar rashin shigar ƙwayoyin cuta a cikin masana'antar, yawan sinadarin hydrophilicity da ƙarancin samuwar ƙwayoyin cuta na gargajiya, haɗakar samfuran JUNAS Time Particle ta hanyar amfani da sinadaran quantum, na iya isa ga fata kai tsaye ta hanyar hanyoyin trans-cellular, intercellular da follicular gumi. Ba tare da lalata tsarin fata ba. Ana ƙara yawan samuwar samfurin sau 5, gami da fiye da kashi 45% a cikin fata, ba tare da lalata tsarin fata ba. An cimma ci gaba mai mahimmanci na tasirin shigar ƙwayoyin cuta da lokacin zama. Wannan shine irinsa na farko a masana'antar.

Fasahar biocatalysis ta supramolecular

Tsarin narkewar sinadarai na bioenzyme: Ana amfani da sinadarai masu narkewa na supramolecular azaman substrates don haɓaka ayyukan enzyme, haɓaka zaɓin chiral, da cimma babban tsarki.

Injiniyan fennel kore fermentation: zaɓi tsire-tsire masu halaye, haɓaka abun ciki na sinadaran aiki, dabarar da ba ta da ruwa, inganta ingancin gabaɗaya

Fasaha ta fermentation ta micellar ta baya: tantance nau'ikan halaye, man kayan lambu mai fermentation, ƙarin tasirin, inganta jin fata da haɓaka sha

Dangane da fasahar kwayoyin halitta masu sake haɗawa, fasahar cloning na kwayoyin halitta mataki ɗaya da fasahar catalytic mai yawan yawa ta bioenzyme, ana amfani da ƙwayoyin cuta da aka ƙera ta hanyar halitta azaman masu ɗaukar sinadarai masu haɓaka sinadarai don samar da abubuwa masu aiki da yawa:

A ƙarƙashin tsarin narkewar abinci mai ƙarfi na supramolecular, enzyme yana nuna babban aiki, zaɓi da kwanciyar hankali, yawan amfani da kayan ƙasa, ƙarancin gurɓatawa a cikin tsarin samarwa, yanayin amsawa mai sauƙi, ingantaccen aiki na aminci da aikin samarwa.

Fasahar fermentation ta micelle ta baya:

Man fetur na halitta da aka zaɓa tare da halayen Sinanci an ƙera su ne kawai don samar da surfactants a ƙarƙashin aikin ƙwayoyin cuta da aka ƙera ta hanyar halitta. An haɗa shi azaman mai ɗaukar nauyin ƙwayar anti-micellar don ƙirƙirar naɗaɗɗen ƙwayar anti-micellar na sinadaran aiki masu narkewa cikin ruwa don cimma yanayin aikace-aikace masu wadata, ƙwarewar fata ta ƙarshe, da ingantaccen tasiri, ƙwarewa, da tasiri mai mahimmanci.

Fasahar ƙara girman ƙwayoyin halitta ta sama

Sifofin Fasaha: Liposome encapsulation, sakin ƙwayoyin fata da aka yi niyya, sakin gashin gashi da aka yi niyya, da kuma sakin abubuwan da ke haifar da kumburi.

Fa'idodi: Nanoization, isar da sako daidai, sakin aiki mai ɗorewa na dogon lokaci, rage ƙaiƙayi, inganta kwanciyar hankali, da kuma haɓaka iskar oxygen

Misalan sinadaran: astaxanthin, glabridin, bitamin A, peptide na jan ƙarfe mai shuɗi, biotin, ceramide, man fetur mai mahimmanci na shuka

Fasahar microencapsulation ta Supramolecular ta dogara ne akan liposome, fat emulsion, fasahar daidaita ruwa mai ionic, fasahar sakin fata mai niyya ga ƙwayoyin fata, fasahar sakin gashi mai niyya ga ƙwayoyin gashi, da fasahar sakin kumburi mai amsawa ga abubuwan kumburi. Ta hanyar ƙirƙirar hanyoyin jigilar roba, samfurin zai iya isar da sinadaran aiki daidai. Yana da kyakkyawan ƙimar sha na transdermal, tsawon lokaci da kwanciyar hankali mai kyau a wurin da fata ke so. Hakanan yana da ƙarancin farashi da aikace-aikace masu inganci a fannin kayan kwalliya, abinci mai aiki da magunguna.

Fasahar haɗa kai ta Peptide

Siffofin Fasaha: Tsarin farko na masana'antar, wanda aka yi niyya ga tsarin matakai da yawa na sarƙoƙin amino acid da polypeptides, gajerun peptides da aka haɗa kai, polypeptides na supramolecular

Jagorar Fasaha: Inganta amphiphilicity, haɓaka kwanciyar hankali da juriyar zafi, rage guba da damuwa na rigakafi, haɓaka sha, da kuma haɗa kai

Misalan sinadaran: supramolecular carnosine, yeast protein peptide

Haɗa kai da sunadarai da peptides ba wai kawai yana ko'ina a cikin tsarin rayuwa ba ne, har ma yana da kyau ga jikin ɗan adam, kuma yana ɗaya daga cikin hanyoyin da suka fi tasiri wajen haɗa kayan nano-biological. Tsarin haɗa kai na peptide tsari ne na haɗa kai, kuma "tsarin zipper na polar amino acid" sabon nau'in tsari ne na sakandare, wanda ke da amfani ga haɗa kai na peptides don samar da tarin abubuwa da aka tsara.

Ana iya cimma daidaiton girman gajerun peptides ta hanyar canza yanayin hydrophobic da kuma reshe na sarkar gefe na ragowar hydrophobic.

Dangane da bayanan ProteinDataBank (PDB) na Shinehigh Innovation, a haɗa shi da lura da gwaje-gwaje na tsari, yanayin ƙwayoyin halitta da lissafin sunadarai na quantum don nazarin tsarin ƙwayoyin peptide, sannan a daidaita su da ƙwayoyin haɗuwa masu ƙarfi. Daidaita nau'in, adadi da matsayin amino acid tsakanin ƙwayoyin peptide don canza takamaiman tsarin naɗewa, ta haka ne inganta ikon ƙwayoyin don haɗuwa da kansu. A fahimci ƙa'idar da aka yi niyya ga peptides. Peptide ɗin da aka haɗa da kansa yana da kyakkyawan amphiphilicity da daidaitawa, wanda ke inganta kwanciyar hankali na peptide, ikon transdermal da bioavailability sosai.